Pep Guardiola is likely to be without three key players for the FA Cup trip to Cheltenham.
At the press conference held today, Guardiola confirmed that De Bruyne will remain out of the green field for four to six weeks.
On the other hand, the Spanish technician will not be able to count on Sergio Aguero, who tested positive for coronavirus.
Also, Kyle Walker has suffered an injury in midweek, so it is doubtful whether he will be ready for the next game.
Manchester City plays tomorrow against Cheltenham in the FA Cup starting at 18:30.